Dosage ; see below
Combinations ; - see below
| Fosinopril More info | |
|---|---|
| Mode Of Action | Inhibition of the conversion of angiotensin I to angiotensin II. |
| Drug Indication | Hypertension |
| Precautions | Severe CCF, impaired renal function, lactation, aortic stenosis, NSAIDs, monitor serum lithium levels, first dose may cause hypotension especially in dehydrated cases, low sodium serum levels, diuretic treated cases, monitor renal function, may potentiate hypoglyceamic effects of insulin or oral hypoglycaemic agents, haematological monitoring. Avoid potassium sparing diuretics or potassium supplements. |
| Contra-Indications | Pregnancy, history of angioneurotic oedema with previous ACE inhibitors, hypersensitivity, renal vascular disease, porphyria. |
| Side Effects | Persistent dry cough, voice changes, chest pain, taste disturbances, bronchospasm, blood dyscrasias, tachycardia, increased serum potassium levels, anaphylactic reactions, hepatic /renal impairment, hypotension, GI disturbances, muscle cramps, sleep disturbances, flushing, asthenia, impotence, CVS disorders. |
| Dosage | Hypertension, initially 10mg daily, increased if necessary after 4 weeks; usual dose range 10-40mg (doses over 40mg not shown to increase efficacy). Heart failure (adjunct), initially 10mg once daily under close medical supervision, increased gradually to 40mg once daily if tolerated. |
| Pregnancy Category | Category D |
| Pregnancy Category Description | Drugs, which have caused, are suspected to have caused, or may be expected to cause an increased rise in the frequency of malformations or irreversible damage. These drugs may also have adverse pharmacological effects required required |
| Drug Category | DRUGS ACTI NG ON THE CARDIO-VASCULAR SYSTEM |
| Drug Sub-Category | Angiotensin-converting enzyme inhibitors |